Toxicology and Drug Discovery

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Toxicology & Drug Discovery Services – KJ REDY BIOSCIENCES

We are committed to help the pharmaceutical business with its research and development needs. Our services span every step of the research and development process, from lead optimisation and preclinical development to target discovery and validation. To successfully discover possible drug candidates, we use a multidisciplinary approach that includes computational toxicology, high-throughput screening, computational chemistry, in vitro pharmacology, toxicology, molecular biology, and disease pathway analysis. We provide significant data on how chemical compounds interact with biological targets, elucidating their pharmacological potential, using a variety of assays, including as receptor binding, enzyme inhibition, and cell-based functional assays. We provide several in vivo efficacy models to further confirm the pharmacodynamics of lead drugs, dosage response, and efficacy. Drug metabolism and pharmacokinetics (DMPK) studies, which assess absorption, distribution, metabolism, and excretion of compounds are another area of knowledge we expertise. The bioavailability, half-life, and clearance data from these investigations are crucial for predicting human profiles and optimising dosage schedules. Notably, our all-inclusive package is developed in accordance with the product specification to guarantee that it contains all required studies, such as IND and NDA enabling studies, impurity qualifying & bridging studies for regulatory submissions, and 505 (B2) methods. Along with developing suitable formulations for lead compounds, we work with our customers to improve their stability, bioavailability, and compliance. This ensures that prospective drug candidates are effectively delivered to the target location for the best possible therapeutic effects. Leading by subject matter experts, our interdisciplinary scientific team will assist our clients in submitting their projects successfully and on schedule.

Why Choose Us?

  • Expert Team: Guided by subject matter experts, our interdisciplinary team ensures accurate and reliable results for all stages of drug discovery and toxicology testing.
  • Comprehensive Service: We offer an end-to-end solution that includes IND and NDA enabling studies, impurity qualifying, and regulatory submission support.
  • Robust & Tailored Solutions: Our services are designed to meet your specific needs and to optimize drug candidate development.

In vivo toxicity studies (Species: Mice, Rats, Rabbits, Guinea Pigs)

  • Acute to chronic toxicity
  • Developmental and reproductive toxicity
  • Carcinogenicity
  • Systemic toxicity
  • Maximum tolerated dose determination
  • Immunotoxicity
  • Endocrine disruption
  • Acute dermal toxicity
  • Skin sensitization
  • Eye irritation
  • Histopathology
  • Hematology and clinical chemistry

Efficacy studies (Species: Mice, Rats, Rabbits, Guinea Pigs)

  • Oncology
  • Pain and inflammation
  • Central nervous system activity
  • Gastrointestinal system activity
  • Metabolic disorders
  • Surgically or chemically induced animal models
  • Cardiovascular disorders
  • Ophthalmic diseases
  • Biomarker analysis
  • Dose-response relationship studies
  • Clinical trial support

In vitro, in vivo & in silico DMPK studies

  • Cytochrome P450 inhibition
  • Cytochrome P450 induction
  • Metabolite identification
  • Microsomal binding and stability
  • Hepatocyte stability
  • Plasma protein binding
  • Plasma/whole blood stability
  • Blood to plasma ratio
  • In vitro absorption, excretion, tissue distribution, and blood-brain barrier profiling
  • Cell-based assays
  • Evaluation of drug metabolism pathways
  • Pharmacokinetic modeling and simulation
  • Drug-drug interaction studies

Safety pharmacology studies

  • Cardiovascular safety assessment
  • Respiratory system safety assessment
  • Gastrointestinal system safety assessment
  • Renal and urinary system safety assessment
  • Ocular safety assessment
  • Hepatic and metabolic safety assessment
  • Central nervous system safety assessment
  • Reproductive and developmental safety assessment
  • Immune system safety assessment

Our Testing Facility